The left-back has had to make do with cup appearances so far this term but comes in in place of Ashley Young.
Jose Mourinho has made various other changes though.
Phil Jones returns from injury to replace Marcos Rojo, who hurt his head in the 2-1 defeat to Man City on Sunday.
Scott McTominay, like Shaw, also gets his first Premier League appearance of the season, replacing Ander Herrera in midfield.
The only other change from the defeat to Man City is Marcus Rashford – who scored in that game – being replaced by Juan Mata.
Manchester United start the game trailing league leaders Man City by 11 points.
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